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Member Forum >> Main Forums >> What Else is New? Interesting Finds from Other Places >> Bergamot extract Increases HDL by up to 42% and reduces LDL by up to 39% without side effects
Bergamot extract Increases HDL by up to 42% and reduces LDL by up to 39% without side effects
Author Topic
searcher7

Master Contributor

Posted: 4/1/2011 3:07:01 AM

The claims on the BergaMet website http://www.bergamet.com/index.php  and on TV programs sound too good to be true.

There are 2 videos on the website.

Citrus Bergamot has undergone a double blind placebo clinical trial at the University of Rome and at the Vascular Medicine and Atherosclerosis Unit Cardiology,Villa Salus Medical Center,Marinella that indicates the following results:
*Increases HDL by up to 42%
*Reduces LDL by up to 39%
*Reduces triglycerides by up to38%
*Reduces total cholesterol by up to 31%
*Reduces blood glucose by up to 22%
*Supports healthy weight loss through improved metabolism.

The Calabrian region in Southern Italy accounts for 80% of the worldwide production of Bergamot
which differs from other citrus fruits because of the high levels of flavonoids which possess a structure similar to statins and exhibit statin like properties without the side effects.The Calabrian mafia operates in this region of Italy.

The recommended dose of BergaMet is 2 capsules twice daily,10minutes before main meals.Each bottle contains 60 vegetarian capsules which each contain 250mg of pure juice Bergamot dehydrated (equivalent to 25% in composition of polyphenols) and 25 mg of ascorbic acid.

The active ingredients in bergamot are neoeriocitrin, naringin, neohesperidin, ponceritin, melitidin, and brutelidin. Melitidin and brutelidin, only recently discovered, exist only in citrus bergamot, and exhibit statin-like properties.

Research

Mollace.V, Muscoli.S, Janda.E, Sacco.I, Ventrice.D, Iannone.M, Visalli.V, Rotiroti. D, Romeo.F
Hypolipemic and Hypoglycaemic activity of bergamot polyphenol: from animal studies to human studies. J.Fitoterapia Vol 81 Issue 8

Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or not with hyperglycaemia. BPF, given orally for 30 days to both rats and patients, reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a significant decrease in blood glucose. Moreover, BPF inhibited HMG-CoA reductase activity and enhanced reactive vasodilation thus representing an efficient phytotherapeutic approach in combating hyperlipemic and hyperglycaemic disorders.



Di Donna.L, De Luca.G, Mazzotti.F, Napoli.A, Salerno.R, Taverna.D, Sindona.G. (2009) Statin- like principles of bergamot fruit ( Citrus bergamia ): isolation of 3-hydroxymethylglutaryl flavonoid. J Nat Prod. 72: 1352-1354
The 3-hydroxy-3-methylglutaryl neohesperidosides of hesperetin (brutieridin, 1) and naringenin (melitidin, 2) were isolated and detected from the fruits of bergamot (Citrus bergamia). The structures of these compounds were determined by spectroscopic and chemical methods
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Vinson.J, Liang.X, Proch.J, Hontz.B, Dancel.J, Sandone.N. (2002).
Polyphenol antioxidant in citrus juices, in vitro and in vivo studies relevant to heart disease. Adv Exp Med Biol 505: 113-122.

Yu.J, Wang.L, Walzem.R.L, Miller.E.G, Pike. L.M, Patil.B.S. (2005). Antioxidant activity of citrus
Limonoids, flavonoids and courmarins. J. Agric Food Chem 53: 2009-2014
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Miceli N, Mondello MR, Monforte MT, Sdrafkakis V, Dugo P, Crupi ML, Taviano MF, De Pasquale R, Trovato A.

Hypolipidemic effects of Cirus bergamia Risso et Poiteau juice in rats fed a hypercholesterolemic diet.
J Agric Food Chem 2007 Dec 26:55(26):10671-7

Pharmaco-Biological Department, University of Messina, Italy.

Citrus bergamia Risso et Poiteau fruits have been traditionally utilized, in Calabria (Italy), as a popular remedy for their hypolipidemic properties. C. bergamia juice total phenol content (2474.35+/-38 microg/mL) was evaluated by the Folin-Ciocalteu method; moreover, HPLC analysis led to the identification of naringin (520 ppm), neoeriocitrin (370 ppm), and neohesperidin (310 ppm). The present study was designed to investigate the hypolipidemic effects of C. bergamia juice and its protective effect on liver of hyperlipidemic rats. Chronic administration of C. bergamia (1 mL/rat/day) provoked a significant reduction in serum cholesterol, triglycerides, and low-density lipoprotein (LDL) levels and an increase in high-density lipoprotein (HDL) levels; moreover, histopathological observations showed, in rats submitted to C. bergamia treatment, a protection of hepatic parenchyma. In addition, fecal neutral sterols and fecal bile acid excretion was found to be increased after C. bergamia treatment. These results suggest that the hypocholesterolemic effect of C. bergamia may be mediated by the increase in fecal neutral sterols and total bile acids excretion. In addition to the hypolipidemic effect, the juice shows radical scavenging activity in the diphenylpicrylhydrazyl (DPPH) test; probably the two effects are related. These observations suggest that the positive intake of C. bergamia may reduce the risk of some cardiovascular diseases through its radical scavenging function and hypocholesterolemic action

Mollace.V, Ragusa.S, Sacco.I, Muscoli.C, Sculco.F, Visalli.V, Palma.E, Muscoli.S, Mondello.L, et al (2008). The protective effect of bergamot oil extract on lecitine like oxy LDL receptor-1 expression In balloon injury-related neointima formation. J Cardiovasc Pharmacol Ther 13: 120-129

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Li.J.M,Che.C.T,Lau.C.B,Leung.P.S,Cheng.C.H,(2006).inhibition of intestinal and renal Na+glucose cotransporter by naringenin.Int J Biochem Cell Biol 38:985-995





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searcher7

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Posted: 4/1/2011 4:38:20 AM

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HeartHawk

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Posted: 4/1/2011 5:20:28 AM

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searcher7

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Posted: 4/1/2011 3:29:54 PM

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spunk88

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Posted: 4/1/2011 7:22:20 PM

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healthnut

Master Contributor

Posted: 4/1/2011 8:47:56 PM

I love the flavor of Earl Grey Tea which contains bergamot! 

Bergamot is in the 'bitter orange' family. Bitter orange is a thermogenic containing synephrine.




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muirsan

Master Contributor

Posted: 4/1/2011 10:09:07 PM

HeartHawk - Dr. Vincenzo Mollace, MD makes such a claim around the 10 minute mark.  

hpingredients.com/index.html





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searcher7

Master Contributor

Posted: 4/2/2011 3:49:16 AM

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sergad

Master Contributor

Posted: 4/2/2011 8:45:43 AM

I am a sample study of one, but tried this for a month to no avail, no improvement in lipids or blood sugar.



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HeartHawk

Administrator

Posted: 4/2/2011 12:27:19 PM

sergad:

Thanks for the valuable input!  Any others?

HH 


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Barkeater

Master Contributor

Posted: 4/3/2011 8:26:46 AM

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searcher7

Master Contributor

Posted: 4/5/2011 4:13:00 PM

The Italian researchers are going to continue their research on the bergamot extract until they
have tested it on 1,000 people.


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Vladimir

Master Contributor

Posted: 4/5/2011 4:59:12 PM

Should I switch my green tea for Earl Grey?



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searcher7

Master Contributor

Posted: 4/6/2011 1:55:57 AM

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FCT

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Posted: 7/10/2012 9:11:50 PM

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searcher7

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Posted: 7/10/2012 10:46:27 PM

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ptheut

Master Contributor

Posted: 7/11/2012 10:16:20 AM

to Searcher:  keep the info coming - - - another solid data point



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jgoldstrich

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Posted: 7/11/2012 2:20:55 PM

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spunk88

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Posted: 7/23/2013 6:49:25 PM

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jgoldstrich

Master Contributor

Posted: 7/24/2013 10:27:04 AM

Thanks for the compliment, Stuart. I had an HDL test in January, but I had the flu at the time and my inflammatory markers were elevated. Will repeat soon.


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christinaw

Master Contributor

Posted: 7/24/2013 6:50:18 PM

I ordered 2 bottles to try it.  Should be delivered soon, maybe Friday.

I have never tried a statin, so it will be interesting to see what it does.



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